phosphotungstic acidcatalyzed strecker three-component reaction of amino acids, aldehydes, and trimethylsilyl cyanide

نویسندگان

saeed balalaie

fatemeh tahoori

negin khatibi

چکیده

a simple and efficient one-pot, three-component strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α-amino nitriles. the reaction was carried out in the presence of catalytic amount of phosphotungstic acid (h3[p(w3o10)4]) as an environmentally friendly catalyst.

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منابع مشابه

Phosphotungstic Acidcatalyzed Strecker Three-Component Reaction of Amino Acids, Aldehydes, and Trimethylsilyl Cyanide

A simple and efficient one-pot, three-component Strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α-amino nitriles. The reaction was carried out in the presence of catalytic amount of phosphotungstic acid (H3[P(W3O10)4]) as an environmentally friendly cata...

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Kinetics and mechanism of the racemic addition of trimethylsilyl cyanide to aldehydes catalysed by Lewis bases.

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عنوان ژورنال:
organic chemistry research

ناشر: iranian chemical society

ISSN

دوره 1

شماره 1 2015

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